Madden NFL 07

Largely invisible to the mainstream, sightless gamers help each other tackle titles like Rock Band and Left 4 Dead, while others focus on games made for--and by--the blind.

Game publisher and gridiron guru will continue relationship despite EA's deal with ESPN and Madden's departure from ABC in 2006.

Wii Remote pack-in leads list of all-time titles; Guitar Hero III, GTA: San Andreas, Modern Warfare 2, Wii Fit, Mario Kart Wii, Call of Duty 4, Madden NFL 07, COD: World at War, and Namco Museum also make chart.