Talbot, that dirty SOB who harasses Drake and company throughout the game, does several thing throughout the game that are not explained (or if so, not very well). He is (spoiler) (spoiler) (spoiler) able to live from being shot by Charlie, is able to teleport away after drugging Charlie, and happens to have access to the hallucinogenic water that is only available in Ubar. There are a couple of explanations:

Number 1: He is simply using black op techniques to make himself seem more threatning. Such as when is shot, he's probably wearing a bulletproof vest; when he (supposedly) teleports away from Charlie, he could have used a secret tunnel; as for the hallucinogenic water, it could have simply been some similar formula that he or someone else made.

Number 2: Everyone of these scenes happens during some drug-induced hallucination; such as when Charlie shoots Talbot, he could still be under the influence; same as when he disappears after drugging Charlie. However, that doesn't explain the drugs he had, so feel free to mix-n-match 1 & 2.

Number 3 (my favorite explanation): Talbot is a Djinn (as in those impossibly hard flame-skull demons). That would explain how he could teleport, survive one bullet, and have access to the hallucogenic water (what exactly that entails is up for debate). It perfectly explains every apparent "plot-hole" (I hate when people usae that word) in the game (that has to do with Talbot, anyway)

I hope these explanations have helped shed more light on that rat Talbot. (who, by the way, is my favorite Uncharted antagonist).